Lipid Lowering Potential of Kamias (Averrhoa bilimbi) Fruit and Leaf Extracts Formulated as Capsule

Ferlien Mae G. Baula, Kessel B. Demetrio, Agnes B. Indig, Elsa Mae M. Numancia, Kathleen Ashley B. Sy, Rhoselyn R. Ybanez

Abstract


Hypercholesterolemia is a disorder that results to narrowing of the arteries that cause atherosclerosis which is a disease of the heart and vascular system that are the leading causes of mortality in the Philippines. Plants have different potentials and are used primarily to treat diseases. One of these plants that are commonly available in the Philippines is Kamias (Averrhoa bilimbi). It consists of functional groups of cyclic ether and alcohol that indicates saponin as the main and active ingredient that has the ability to eliminate lipids. The fruit and leaf
extracts of the plant were lyophilized and formulated as capsule. It was
administered to the test animal to determine its anti hyperlipidemic effect. This research determines the acute oral toxicity dose, approximate effective dose and significant difference of Kamias leaf and fruit extracts. The statistical tool used in this study was Dependent T-test to compare the effectiveness of fruit and leaf extract of Kamias (Averrhoa bilimbi). It suggested that both fruit and leaf extracts showed non toxic at the dose of 2000 mg/kg. Formulated capsule of Kamias (Averrhoa bilimbi) appeared to have significant difference between the fruit and leaf ethanolic extracts and negative control which is the placebo on its
lipid lowering activity.


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